Building integrated molecular landscapes of complex diseases

Molecular Landscapes To Identify Novel Biomarkers And Drug Targets

novel biomarkers and drug targets within reach

We integrate the wealth of omics data into molecular landscapes

Our approach

Unbiased and Curated

Our ‘molecular landscape building approach‘ is an unique method to integrate omics and functional data for any complex disease. Our approach always starts from unbiased genome-wide data, and offers a new platform for data integration, gene enrichment, protein-protein interactions and the application of bioinformatics-based tools. In addition, our data is evidence-based and manually curated to provide the utmost accuracy and reliabilty of the uncovered underlying pathways, and is integrated with corroborating evidence and findings from extensive systematic literature searches and evaluations.

Generating Hypotheses

Our landscapes integrate all available omics data. This enables us to identify pathways and themes that are associated with each disease, and generate novel hypothesis about the biological mechanisms underlying the disease.

Target Identification

Based on the molecular landscape of each disease, we can pinpoint converging pathways and protein hubs that are important for disease etiology, and we can identify drug targets. In order to qualify as valid targets, the identified targets have to meet stringent criteria – for example tissue/substrate specificity, temporal specificity, and (additional) function as a biomarker. These drug targets can then be validated in preclinical studies and subsequently used as new leads for drug development.

Services

DATA ANALYSIS

Analyzing omics with cutting edge bioinformatic tools and methods.

DATA INTEGRATION

Integration of large sets of omics and functional data sources.

Consultancy

Sharing our expertise and supporting research on complex genetic diseases

Partners & Clients

Dompé logo

Dompé

Harvard Medical School

Nationaal-MS-Fonds-logo

Nationaal MS Fonds

PRIME

PRISM logo

PRISM

Radboud UMC

Radboud UMC

Servier_logo

Servier

Takeda logo

Takeda

Our Team

Geert Poelmans, M.D., Ph.D.

Director

Koen Klemann, Ph.D.

Senior Project Manager

Ward De Witte, B.Sc.

Bioinformatician

Joanna Widomska, M.Sc.

Researcher

Hyun Ruisch, M.D., Ph.D.

Researcher

Robert van der Linden Ph.D.

Researcher

Marco Heerings, M.A.N.P.

Researcher

Contact us

Drug Target ID B.V.

Toernooiveld 200, 6525 EC, Nijmegen, The Netherlands
Telephone: +31 (0)6 30345956
E-mail: geert.poelmans@drugtargetid.com
Drug Target ID is a limited (Ltd.) company Established: 15 October 2012 Establishment#: 000025829335 Chamber of Commerce#: 56257872