We have developed a highly novel and unique ‘molecular landscape building approach’ that is hypothesis free. We apply gene-enrichment and protein-protein interaction tools, and literature analyses to the top-list findings from several types of genetic studies. These studies include genome-wide association studies (GWAS), candidate gene association studies, (genome-wide) sequencing studies, copy-number variation (CNV) studies, gene expression studies, and studies on (genetic) animal models. Thus far, we have successfully applied our approach to the neuropsychiatric and neurological disorders dyslexia, attention-deficit hyperactivity disorder (ADHD), motor coordination problems, autism spectrum disorders (ASDs) (1-5), schizophrenia, Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). We have also applied the same approach to a number of other complex non-neurological disorders, such as congenital anomalies of the kidney and urinary tract (CAKUT) and cleft lip/palate (CLP). The built landscapes represent the underlying core biological process(es) for a given disorder and, importantly, they are clearly more comprehensive than the currently available, hypothesis-driven landscapes (e.g. a substantially higher number of components are present in our detailed landscapes).