The figure below shows the molecular landscape for a complex genetic disorder that we have built through applying our approach.
Example landscape for a complex genetic disorder built using our comprehensive ‘molecular landscape building approach’. The figure shows a neuron, in which an integrated protein landscape is located that regulates the function of the neuron and contains a number of novel diagnostic biomarkers and druggable targets. The proteins indicated in blue ovals (cytoplasmic, organellar or extracellular) or rectangles (transmembrane) are encoded by genes that are linked to the genetic disorder through the top-ranked data from all available GWAS for this particular disorder. The yellow ovals indicate proteins encoded by genes that are implicated in the disorder through genetic evidence other than GWAS. The orange ovals/rectangles represent genes that are differentially expressed in patients. The red borders indicate proteins encoded by familial candidate genes. White ovals/rectangles represent proteins that are not (yet) genetically linked to the disorder but functionally link a number of signaling cascades within the landscape. For reasons of nondisclosure, the protein names have been generalized.